KLF2 mediates enhanced chemoreflex sensitivity, disordered breathing and autonomic dysregulation in heart failure
نویسندگان
چکیده
منابع مشابه
Abnormal breathing during sleep and increased central chemoreflex sensitivity in congestive heart failure.
Central Chemoreflex Sensitivity in Congestive Heart Failure To the Editor: The data of Narkiewicz et al1 expand our understanding of the importance of the imbalance between enhanced central versus peripheral chemoreflex sensitivity in the pathophysiology of congestive heart failure. The authors comment on the links between central cardiovascular and respiratory control, but despite this, patien...
متن کاملDysregulation of peripheral and central chemoreflex responses in Chagas' heart disease patients without heart failure.
BACKGROUND The peripheral and central chemoreflexes are important autonomic mechanisms for regulating breathing and cardiovascular function. Although pathological inflammatory infiltration of the peripheral chemoreceptors and central nervous system has been reported in Chagas' disease, functional evaluation of chemoreflexes has not yet been performed. METHODS AND RESULTS The hypothesis that c...
متن کاملPrognosis and sleep disordered breathing in heart failure.
Abnormal breathing in heart failure as originally described by Cheyne and subsequently by Stokes was observed in apparently awake patients as an agonal breathing pattern. “. . . The only peculiarity in the last period of his illness was in the state of the respiration. For several days his breathing was irregular, then it would become perceptible, though very low, then by degrees it became heav...
متن کاملSleep disordered breathing and its treatment in congestive heart failure.
Sleep disordered breathing (SDB) is a common problem with adverse cardiorespiratory, endocrinological, and endothelial effects. Recent studies demonstrate an even higher prevalence of SDB in congestive heart failure (CHF) than in a randomly selected population, with up to 40% and 11% having Cheyne Stokes respiration-central sleep apnoea and obstructive sleep apnoea-hypopnoea syndromes, respecti...
متن کاملSleep‐disordered breathing in heart failure: facts and numbers
Sleep-disordered breathing has a high prevalence in the general population, but is especially prominent in patients with heart failure (HF). HF and sleep-disordered breathing share a bidirectional relationship, with sleep-disordered breathing being both cause and effect of poor cardiac functioning. The high inter-individual variability of symptom presentation can impede the clinical diagnostic ...
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ژورنال
عنوان ژورنال: The Journal of Physiology
سال: 2017
ISSN: 0022-3751
DOI: 10.1113/jp273805